I started running mine higher, at 37 up front and 47 in the back.
I significantly prefer the way it rides much better at these numbers (I'm on the 19"s). The car rides much less 'bouncy' over bumpy and undulating roads (poor condition English country lanes constitute 50% of my miles) and the turn-in handling feels much more precise.
I'm not sure how this will affect wear, though in every other car I have owned I have run a higher pressure and not had any adverse wear. In particular, several sets of tires lasted far beyond the average. How you drive has a significant play on wear.